Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation.

@article{Furukawa2003AlterationIC,
  title={Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation.},
  author={Katsutoshi Furukawa and Yue Wang and Pamela J Yao and Weiming Fu and Mark P. Mattson and Y. Itoyama and Hiroshi Onodera and I. D'Souza and Parvone H Poorkaj and Thomas D. Bird and Gerard D. Schellenberg},
  journal={Journal of neurochemistry},
  year={2003},
  volume={87 2},
  pages={427-36}
}
Tau, a microtubule binding protein, is not only a major component of neurofibrillary tangles in Alzheimer's disease, but also a causative gene for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). We show here that an FTDP-17 tau mutation (V337M) in SH-SY5Y cells reduces microtubule polymerization, increases voltage-dependent calcium current (ICa) density, and decreases ICa rundown. The reduced rundown of ICa by V337M was significantly inhibited by… CONTINUE READING