Alteration in Mir-21/PTEN Expression Modulates Gefitinib Resistance in Non-Small Cell Lung Cancer

@inproceedings{Shen2014AlterationIM,
  title={Alteration in Mir-21/PTEN Expression Modulates Gefitinib Resistance in Non-Small Cell Lung Cancer},
  author={Hua Shen and Fang Zhu and Jinyuan Liu and Tongpeng Xu and Dong Pei and Rong Wang and Yingying Qian and Qi Li and Lin Wang and Zhumei Shi and Jitai Zheng and Qiudan Chen and Bing-hua Jiang and Yongqian Shu},
  booktitle={PloS one},
  year={2014}
}
Resistance to TKI treatment is a major obstacle in effective treatment of NSCLC. Besides EGFR mutation status, the mechanisms involved are largely unknown. Some evidence supports a role for microRNA 21 in modulating drug sensitivity of chemotherapy but its role in NSCLC TKI resistance still remains unexplored. This study aimed to investigate whether NSCLC miR-21 mediated resistance to TKIs also results from Pten targeting. Here, we show miR-21 promotes cancer by negatively regulating Pten… CONTINUE READING

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