Alteration in Glutathione Content and Associated Enzyme Activities in the Synaptic Terminals but not in the Non-synaptic Mitochondria from the Frontal Cortex of Parkinson’s Disease Brains

@article{Harish2012AlterationIG,
  title={Alteration in Glutathione Content and Associated Enzyme Activities in the Synaptic Terminals but not in the Non-synaptic Mitochondria from the Frontal Cortex of Parkinson’s Disease Brains},
  author={Gangadharappa Harish and Anita Mahadevan and Muchukunte Mukunda Srinivas Bharath and Susarla Krishna Shankar},
  journal={Neurochemical Research},
  year={2012},
  volume={38},
  pages={186-200}
}
Altered redox dynamics contribute to physiological aging and Parkinson’s disease (PD). This is reflected in the substantia nigra (SN) of PD patients as lowered antioxidant levels and elevated oxidative damage. Contrary to this observation, we previously reported that non-SN regions such as caudate nucleus and frontal cortex (FC) exhibited elevated… CONTINUE READING