Alteration in Ca2+ homeostasis by a trauma peptide.

  title={Alteration in Ca2+ homeostasis by a trauma peptide.},
  author={David Butler Hoyt and A. Nuri Ozkan and J{\"u}rgen Frevert and Wolfgang G. Junger and William H. Loomis},
  journal={The Journal of surgical research},
  volume={51 6},
Postinjury tissue inflammation with PMN elastase proteolysis generates immunosuppressive fibronectin peptides (FNDP) impairing chemotaxis, T-cell activation, and proliferation. Excess intracellular Ca2+ ([Ca2+]i) impairs T-cell activation. This study quantifies the changes in [Ca2+]i following exposure to a degradation peptide of fibronectin to determine the mechanism of action of these peptides on calcium homeostasis. Isolated human PBLs were exposed to immunosuppressive concentrations of FNDP… CONTINUE READING