Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD

@article{Matar2009AlprazolamTI,
  title={Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD},
  author={Michael Alex Matar and Joseph Zohar and Ze'ev Kaplan and Hagit Cohen},
  journal={European Neuropsychopharmacology},
  year={2009},
  volume={19},
  pages={283-295}
}
Interventions after acute stress prevent its delayed effects on the amygdala
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A decrease in the anxiety index and freezing response indicates the therapeutic potential of curcumin for treating PTSD and the increased cortisol levels reinforce the restoration of HPA-axis function, which normally becomes dysfunctional in PTSD.
The Neurochemical Effects of Prazosin Treatment on Fear Circuitry in a Rat Traumatic Stress Model
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It is demonstrated that prazosin might alleviate defensive behaviors and traumatic stress symptoms when given during the traumatic cue presentation in the stressed rats, however prazoin administration resulted in higher anxiety levels in non stressed rats when the neutral cue was presented.
Maintaining the clinical relevance of animal models in translational studies of post-traumatic stress disorder.
TLDR
Cut-off (inclusion/exclusion) behavioral criteria (CBC) are designed which classify study subjects as being severely, minimally or partially affected by the stress paradigm, to be applied retrospectively in the analysis of behavioral data.
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Immediate postexposure administration of sertraline reduced anxiety-like and avoidant behavior, decreased hyperarousal responses and diminished the overall incidence of extreme (PTSD-like) behavioral responses, compared to the delayed treatment regimen and to saline controls.
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