Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD.

@article{Matar2009AlprazolamTI,
  title={Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD.},
  author={Michael Alex Matar and Joseph Zohar and Z. Furkan Kaplan and Hagit Cohen},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2009},
  volume={19 4},
  pages={283-95}
}
BACKGROUND In light of clinical reports suggesting that early benzodiazepine administration interferes with long-term recovery from traumatic stress, a prospective animal model for PTSD was employed to assess the short- and long-term effects of a brief course of alprazolam following stress exposure. METHOD Animals exposed to stress were treated either 1 h or 7 days later with alprazolam or vehicle for 3-days. Outcome measures included behavior in the elevated plus-maze (EPM) and acoustic… CONTINUE READING

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