Alprazolam increases dehydroepiandrosterone concentrations.

  title={Alprazolam increases dehydroepiandrosterone concentrations.},
  author={Patricia Dowley Kroboth and Firoozeh S Salek and Roslyn A Stone and Richard J. Bertz and Frank J. Kroboth},
  journal={Journal of clinical psychopharmacology},
  volume={19 2},
The gamma-aminobutyric acid (GABA) agonist alprazolam is known to decrease adrenocorticotropic hormone and cortisol concentrations. Dehydroepiandrosterone (DHEA) is secreted synchronously with cortisol by the adrenal glands and demonstrates diurnal variation. The major objective of this study was to determine whether alprazolam affects concentrations of DHEA and DHEA-S, the sulfated metabolite. In vitro studies have demonstrated that DHEA-S, and perhaps DHEA, have GABA antagonistic activity… CONTINUE READING