Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects.

@article{Bertz1997AlprazolamIY,
  title={Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects.},
  author={Richard J. Bertz and Patricia Dowley Kroboth and Frank J. Kroboth and Ian J. Reynolds and Firoozeh S Salek and Charles E. Wright and Randall B. Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={281 3},
  pages={1317-29}
}
This study was designed to determine whether age influences sensitivity to alprazolam and/or rate of acute tolerance development to the effects of alprazolam. Three treatments were each separated by 4 weeks. Twenty-five young (ages 22-35) and 13 elderly (ages 65-75) men received 2 mg of alprazolam/2 min i.v. Blood samples were obtained over 48 hr, and sedative, psychomotor and memory effects were assessed serially for 12 hr. Clearance was lower (P = .05) and elimination t[1/2] was longer (P… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Administration Manual

  • C. T. RANDT, E. R. BROWN
  • Randt Memory Test
  • 1983
Highly Influential
16 Excerpts

Degree and exposure duration affect tolerance to midazolam’s psychomotor effects (abstract)

  • J. C. FLEISHAKER, J. H. CHAMBERS
  • Clin. Pharmacol. Ther
  • 1994

Similar Papers

Loading similar papers…