Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects.

@article{Bertz1997AlprazolamIY,
  title={Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects.},
  author={Richard J. Bertz and Patricia Dowley Kroboth and Frank J. Kroboth and Ian J. Reynolds and Firoozeh S Salek and Charles E. Wright and Randall B. Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={281 3},
  pages={1317-29}
}
This study was designed to determine whether age influences sensitivity to alprazolam and/or rate of acute tolerance development to the effects of alprazolam. Three treatments were each separated by 4 weeks. Twenty-five young (ages 22-35) and 13 elderly (ages 65-75) men received 2 mg of alprazolam/2 min i.v. Blood samples were obtained over 48 hr, and sedative, psychomotor and memory effects were assessed serially for 12 hr. Clearance was lower (P = .05) and elimination t[1/2] was longer (P… CONTINUE READING