Alprazolam blocks the naloxone-stimulated hypothalamo-pituitary-adrenal axis in man.

@article{Torpy1993AlprazolamBT,
  title={Alprazolam blocks the naloxone-stimulated hypothalamo-pituitary-adrenal axis in man.},
  author={David James Torpy and Jeffrey Ernest Grice and Gregory I Hockings and Mary M Walters and Georgina V Crosbie and Richard V Jackson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 2},
  pages={388-91}
}
Alprazolam (APZ) is a benzodiazepine with unique antidepressant activity for a drug of its class. There is some evidence of inhibition of the unstimulated hypothalamo-pituitary-adrenal axis by APZ which may be important in its therapeutic action, and could be detrimental in APZ-treated subjects who encounter stressful stimuli. To assess the effect of APZ on stimulated ACTH and cortisol secretion, we studied 14 normal subjects in a randomized, double-blind, placebo-controlled design. APZ or… CONTINUE READING