Alprazolam augmentation of the antipsychotic effects of fluphenazine in schizophrenic patients. Preliminary results.

@article{Wolkowitz1988AlprazolamAO,
  title={Alprazolam augmentation of the antipsychotic effects of fluphenazine in schizophrenic patients. Preliminary results.},
  author={Owen M. Wolkowitz and Alan Breier and A R Doran and John Kelsoe and Patrick Lucas and Steven M Paul and David Pickar},
  journal={Archives of general psychiatry},
  year={1988},
  volume={45 7},
  pages={664-71}
}
Alprazolam was added, under double-blind conditions, to stable fluphenazine hydrochloride regimens in 12 symptomatic, chronically ill inpatients with schizophrenia. The addition of alprazolam was associated with significant, albeit modest, reductions in global psychosis, thought disorder, and paranoia ratings, with a return to pretreatment levels on discontinuation of alprazolam treatment. Improvement in "negative symptoms" such as emotional withdrawal paralleled the changes in "positive… CONTINUE READING