• DOI:10.1192/BJP.162.6.776
Corpus ID: 25233822

Alprazolam and exposure alone and combined in panic disorder with agoraphobia. A controlled study in London and Toronto.

@article{Marks1993AlprazolamAE,
  title={Alprazolam and exposure alone and combined in panic disorder with agoraphobia. A controlled study in London and Toronto.},
  author={I. Marks and R. Swinson and M. Basoglu and Klaus Kuch and H. Noshirvani and G. O'sullivan and P. Lelliott and M. Kirby and G. McNamee and S. Sengun},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1993},
  volume={162},
  pages={
          776-87
        }
}

• I. Marks, R. Swinson, +7 authors S. Sengun
• Published 1993
• Psychology, Medicine
• The British journal of psychiatry : the journal of mental science

A cross-national randomised trial of alprazolam for chronic panic disorder with agoraphobia was run. Compared with previous trials it had three new features: an exposure therapy contrast group, a six-month treatment-free follow-up, and a low rate of early placebo drop-outs ('non-evaluables'). The dose of alprazolam was high (5 mg/day). The 154 patients had eight weeks of: alprazolam and exposure (combined treatment); or alprazolam and relaxation (a psychological placebo); or placebo and… Expand

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