Alprazolam and Diazepam in the Treatment of Generalized Anxiety

  title={Alprazolam and Diazepam in the Treatment of Generalized Anxiety},
  author={Robert {\'E}lie and Yves Lamontagne},
  journal={Journal of Clinical Psychopharmacology},
In a 4-week double-blind study comparing alprazolam with diazepam treatments, 48 outpatients suffering from mild to moderate generalized anxiety were evaluated after a 5-day placebo washout, and then after 1, 2, and 4 weeks of treatment. The optimal therapeutic doses without excessive sedation averaged 2 mg for alprazolam and 15.8 mg for diazepam. Results from the Hamilton Anxiety Rating Scale, the Clinical Global Impression Scale, a behavior checklist questionnaire, and a symptomatic patients… 

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