Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans.

@article{Giordano2003AlprazolamB,
  title={Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin-induced hypoglycaemia in humans.},
  author={Roberta Giordano and Silvia Grottoli and P C Brossa and Micaela Pellegrino and Silvia Destefanis and Fabio Lanfranco and L. Gianotti and Ezio Ghigo and Emanuela Arvat},
  journal={Clinical endocrinology},
  year={2003},
  volume={59 3},
  pages={314-20}
}
OBJECTIVE Alprazolam (ALP), a benzodiazepine-activating GABAergic receptor, possesses clear centrally mediated inhibitory effects on ACTH and cortisol secretion that could reflect an inhibitory influence on CRH- and/or AVP-secreting neurones. An inhibitory effect of ALP on catecholamine release has also been shown while its effect on GH secretion is unclear. To further clarify the neuroendocrine actions of ALP, we studied the ALP effects on the neurohormonal responses to hypoglycaemia in a… CONTINUE READING