Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

@article{Grandgirard1998AlphavirusesIA,
  title={Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.},
  author={Denis Grandgirard and Elaine J. Studer and Laurent Monney and Thomas Belser and Isabelle Fellay and Christoph Borner and Mark Robert Michel},
  journal={The EMBO journal},
  year={1998},
  volume={17 5},
  pages={1268-78}
}
Bcl-2 oncogene expression plays a role in the establishment of persistent viral infection by blocking virus-induced apoptosis. This might be achieved by preventing virus-induced activation of caspase-3, an IL-1beta-converting enzyme (ICE)-like cysteine protease that has been implicated in the death effector phase of apoptosis. Contrary to this model, we show that three cell types highly overexpressing functional Bcl-2 displayed caspase-3 activation and underwent apoptosis in response to… CONTINUE READING