Alphaviruses and their derived vectors as anti-tumor agents.

  title={Alphaviruses and their derived vectors as anti-tumor agents.},
  author={Gregory J. Atkins and James W P Smyth and Marina N. Fleeton and Sareen Elizabeth Galbraith and Brian J. Sheahan},
  journal={Current cancer drug targets},
  volume={4 7},
The alphaviruses Semliki Forest virus (SFV) and Sindbis virus have recently been developed as prototype anti-cancer agents. These are RNA-containing enveloped viruses that code for only 9 proteins of unique sequence. The standard recombinant SFV vector system consists of suicide particles containing recombinant RNA. In addition, alphavirus vectors capable of limited multiplication in the host are also being developed. Several strategies are being adopted to construct prototype SFV vectors for… CONTINUE READING


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