Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.

@article{Thompson2008AlphavirusRP,
  title={Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.},
  author={Joseph M. Thompson and Alan C. Whitmore and Herman F Staats and R. E. Johnston},
  journal={Vaccine},
  year={2008},
  volume={26 33},
  pages={4267-75}
}
Alphavirus replicon particles induce strong antibody and CD8+ T cell responses to expressed antigens in numerous experimental systems. We have recently demonstrated that Venezuelan equine encephalitis virus replicon particles (VRP) possess adjuvant activity for systemic and mucosal antibody responses. In this report, we demonstrate that VRP induced an increased and balanced serum IgG subtype response to co-delivered antigen, with simultaneous induction of antigen-specific IgG1 and IgG2a… CONTINUE READING

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