Alphaviral vectors for gene transfer into neurons

  title={Alphaviral vectors for gene transfer into neurons},
  author={Markus U. Ehrengruber},
  journal={Molecular Neurobiology},
Alphaviruses are small, enveloped positive-strand RNA viruses that have been successfully transformed into expression vectors in the case of Semliki Forest virus (SFV), Sindbis virus (SIN), and Venezuelan equine encephalitis virus. Compared to other viral vectors, their advantages are easy and fast generation of recombinant viral particles, rapid onset, and high-level transgene expression. When applied to neuronal tissue, SFV and SIN vectors possess the additional advantage of efficiently and… CONTINUE READING