Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion.

@article{Dang2006Alphavbeta3IA,
  title={Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion.},
  author={Dongmin Dang and James R. Bamburg and Daniel M. Ramos},
  journal={Experimental cell research},
  year={2006},
  volume={312 4},
  pages={468-77}
}
Cytoskeletal reorganization is partially mediated through cofilin, an actin assembly regulatory protein. Cofilin activity is modulated by reversible phosphorylation at Ser3. In this study, using K1735 murine melanoma cells, we examined the relationship between beta3-integrin expression, phosphorylation of cofilin, and metalloproteinase production. The… CONTINUE READING