Alphafetoprotein and alphafetoprotein receptor expression in the normal human placenta at term.

@article{Newby2005AlphafetoproteinAA,
  title={Alphafetoprotein and alphafetoprotein receptor expression in the normal human placenta at term.},
  author={Deborah Newby and Gillian L. Dalgliesh and Fiona Lyall and David A. Aitken},
  journal={Placenta},
  year={2005},
  volume={26 2-3},
  pages={
          190-200
        }
}
Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP receptor in uncomplicated pregnancies at term. Immunohistochemistry and Western blotting clearly demonstrated the presence of AFP in villous tissue at term. However, evidence of AFP mRNA… CONTINUE READING

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