AlphaIIbG236E causes Glanzmann thrombasthenia by impairing association with beta3.

@article{Afrasiabi2008AlphaIIbG236ECG,
  title={AlphaIIbG236E causes Glanzmann thrombasthenia by impairing association with beta3.},
  author={Abdolreza Afrasiabi and Fabrizio Gelain and Andrea Artoni and Pier M Mannucci},
  journal={Platelets},
  year={2008},
  volume={19 5},
  pages={322-7}
}
Glanzmann thrombasthenia (GT) is a recessively inherited bleeding disorder caused by the quantitative or qualitative deficiency of the platelet fibrinogen receptor, integrin alphaIIbbeta3. The N-terminal domain of the alphaIIb subunit is folded in a beta-propeller that plays the role of binding fibrinogen and associating with the ligand-binding region of… CONTINUE READING