Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury.

  title={Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury.},
  author={Marni D Boppart and Dean J. Burkin and Stephen J. Kaufman},
  journal={American journal of physiology. Cell physiology},
  volume={290 6},
Alpha7beta1-integrin links laminin in the extracellular matrix with the cell cytoskeleton and therein mediates transduction of mechanical forces into chemical signals. Muscle contraction and stretching ex vivo result in activation of intracellular signaling molecules that are integral to postexercise injury responses. Because alpha7beta1-integrin stabilizes muscle and provides communication between the matrix and cytoskeleton, the role of this integrin in exercise-induced cell signaling and… CONTINUE READING
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