Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells.

@article{Gubbins2010Alpha7NA,
  title={Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells.},
  author={Earl J. Gubbins and Murali M Gopalakrishnan and Jinhe Li},
  journal={Brain research},
  year={2010},
  volume={1328},
  pages={1-11}
}
The alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) plays a fundamental role in Ca(2+)-dependent activation of signaling pathways that can modulate intracellular events involved in learning and memory. Activation of extracellular signal-regulated kinase-1 and -2 (ERK1/2) are well documented Ca(2+) signaling events, but these have not been well characterized in response to alpha7 nAChR-selective ligands. The present study examined activation of ERK1/2 and explored pathways leading to CREB… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin - dependent protein kinase II ( CaMKII ) , p38 MAP kinase and mitogen - activated protein kinase kinase1/2 ( MEK1/2 ) , indicating the involvement of these kinases upstream of ERK1/2 .
ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin - dependent protein kinase II ( CaMKII ) , p38 MAP kinase and mitogen - activated protein kinase kinase1/2 ( MEK1/2 ) , indicating the involvement of these kinases upstream of ERK1/2 .
ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin - dependent protein kinase II ( CaMKII ) , p38 MAP kinase and mitogen - activated protein kinase kinase1/2 ( MEK1/2 ) , indicating the involvement of these kinases upstream of ERK1/2 .
ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin - dependent protein kinase II ( CaMKII ) , p38 MAP kinase and mitogen - activated protein kinase kinase1/2 ( MEK1/2 ) , indicating the involvement of these kinases upstream of ERK1/2 .
ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin - dependent protein kinase II ( CaMKII ) , p38 MAP kinase and mitogen - activated protein kinase kinase1/2 ( MEK1/2 ) , indicating the involvement of these kinases upstream of ERK1/2 .
ERK1/2 phosphorylation was also attenuated by inhibitors of calmodulin - dependent protein kinase II ( CaMKII ) , p38 MAP kinase and mitogen - activated protein kinase kinase1/2 ( MEK1/2 ) , indicating the involvement of these kinases upstream of ERK1/2 .
All Topics