Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating.

@article{Radek2006Alpha4beta2NR,
  title={Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating.},
  author={Richard J. Radek and Holly M. Miner and Natalie A. Bratcher and Michael W. Decker and Murali M Gopalakrishnan and Robert Scott Bitner},
  journal={Psychopharmacology},
  year={2006},
  volume={187 1},
  pages={47-55}
}
RATIONALE Nicotine improves the deficiencies of sensory gating function in schizophrenic patients and in dilute brown non-Agouti (DBA/2) mice. This effect of nicotine has been attributed to activation of the alpha7 nicotinic acetylcholine receptor (nAChR) subtype. OBJECTIVE The aim of this study was to determine whether the activation of another nAChR subtype, the central nervous system (CNS) prominent alpha4beta2 receptor, also contributes to the effects of nicotine on sensory gating in DBA… CONTINUE READING

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