Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function.

@article{Fleming2008Alpha4beta1IB,
  title={Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function.},
  author={Jennifer C. Fleming and Feng Bao and Yuhua Chen and Eilis F Hamilton and Jane K. Relton and Lynne C. Weaver},
  journal={Experimental neurology},
  year={2008},
  volume={214 2},
  pages={147-59}
}
The extent of disability caused by spinal cord injury (SCI) relates to secondary tissue destruction arising partly from an intraspinal influx of neutrophils and monocyte/macrophages after the initial injury. The integrin alpha4beta1, expressed by these leukocytes, is a key to their activation and migration into/within tissue. Therefore, blocking this integrin's functions may afford significant neuroprotection. Rats were treated intravenously with a blocking monoclonal antibody (mAb) to the… CONTINUE READING