Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

@article{Mcconnell2010Alpha4IA,
  title={Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.},
  author={J. L. Mcconnell and Guy R. Watkins and Sarah E. Soss and Heidi S Franz and Lisa R McCorvey and Benjamin W. Spiller and Walter J Chazin and Brian E. Wadzinski},
  journal={Biochemistry},
  year={2010},
  volume={49 8},
  pages={
          1713-8
        }
}
Multiple regulatory mechanisms control the activity of the protein serine/threonine phosphatase 2A catalytic subunit (PP2Ac), including post-translational modifications and its association with regulatory subunits and interacting proteins. Alpha4 is a PP2Ac-interacting protein that is hypothesized to play a role in PP2Ac ubiquitination via its interaction with the E3 ubiquitin ligase Mid1. In this report, we show that alpha4 serves as a necessary adaptor protein that provides a binding platform… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

Dynamic ubiquitin signaling in cell cycle regulation

  • The Journal of cell biology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Structure and ubiquitin binding of the ubiquitin-interacting motif.

  • The Journal of biological chemistry
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL