Alpha4 integrins and the immune response.

  title={Alpha4 integrins and the immune response.},
  author={David Rose and Jaewon Han and Mark H Ginsberg},
  journal={Immunological reviews},
The alpha4 integrins (alpha4beta1 and alpha4beta7) play multiple roles in the immune system. Alpha4 integrins impact hematopoiesis, leukocyte trafficking in immune surveillance and inflammation, and leukocyte activation and survival. To perform these functions, alpha4 integrins act as both adhesive and signaling receptors. Paxillin, a signaling adapter molecule, binds directly to the alpha4 subunit cytoplasmic domain, and its binding is regulated by serine phosphorylation of the alpha4 subunit… CONTINUE READING
Highly Cited
This paper has 126 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 61 extracted citations

The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking

Experimental & Molecular Medicine • 2006
View 4 Excerpts
Highly Influenced

126 Citations

Citations per Year
Semantic Scholar estimates that this publication has 126 citations based on the available data.

See our FAQ for additional information.