Alpha4 integrins and the immune response.

@article{Rose2002Alpha4IA,
  title={Alpha4 integrins and the immune response.},
  author={David Rose and Jaewon Han and Mark H Ginsberg},
  journal={Immunological reviews},
  year={2002},
  volume={186},
  pages={
          118-24
        }
}
The alpha4 integrins (alpha4beta1 and alpha4beta7) play multiple roles in the immune system. Alpha4 integrins impact hematopoiesis, leukocyte trafficking in immune surveillance and inflammation, and leukocyte activation and survival. To perform these functions, alpha4 integrins act as both adhesive and signaling receptors. Paxillin, a signaling adapter molecule, binds directly to the alpha4 subunit cytoplasmic domain, and its binding is regulated by serine phosphorylation of the alpha4 subunit… CONTINUE READING
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