Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.

@article{Shi2007Alpha2chimaerinIW,
  title={Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.},
  author={Lei Shi and Wing-Yu Fu and K Hung and Cassandra Porchetta and Christine Hall and Amy K. Y. Fu and Nancy Y Ip},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 41},
  pages={16347-52}
}
EphA4-dependent growth cone collapse requires reorganization of actin cytoskeleton through coordinated activation of Rho family GTPases. Whereas various guanine exchange factors have recently been identified to be involved in EphA4-mediated regulation of Rho GTPases and growth cone collapse, the functional roles of GTPase-activating proteins in the process are largely unknown. Here we report that EphA4 interacts with alpha2-chimaerin through its Src homology 2 domain. Activated EphA4 induces a… CONTINUE READING

From This Paper

Topics from this paper.
45 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…