Alpha2 adrenoceptors modulate histamine release from sympathetic nerves in the guinea pig vas deferens

  title={Alpha2 adrenoceptors modulate histamine release from sympathetic nerves in the guinea pig vas deferens},
  author={Gonghao He and Xue Ma and Jun Lu and Jing-ru Meng and Ying-ying Chen and Min Jia and Xiaoxing Luo},
In our previous studies, we have identified that histamine (HA) is co-released with noradrenaline (NA) from the sympathetic nerve terminals and acts as a novel sympathetic neurotransmitter. However, the modulation of sympathetic HA release by sympathetic prejunctional receptors is still unknown. Therefore, in this study, we explored the modulation effect of alpha(2) adrenoceptors on sympathetic HA release and the interaction of alpha(2) adrenoceptors with HA H(3) receptors in vas deferens… Expand
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