Alpha2-adrenergic receptors modify dendritic spike generation via HCN channels in the prefrontal cortex.

@article{Barth2008Alpha2adrenergicRM,
  title={Alpha2-adrenergic receptors modify dendritic spike generation via HCN channels in the prefrontal cortex.},
  author={Albert M I Barth and E Sylvester Vizi and Tibor Zelles and Bal{\'a}zs Lendvai},
  journal={Journal of neurophysiology},
  year={2008},
  volume={99 1},
  pages={394-401}
}
  • Albert M I Barth, E Sylvester Vizi, +1 author Balázs Lendvai
  • Published 2008 in Journal of neurophysiology
Although dendritic spikes are generally thought to be restricted to the distal apical dendrite, we know very little about the possible modulatory mechanisms that set the spatial limits of dendritic spikes. Our experiments demonstrated that high-frequency trains of backpropagating action potentials avoided filtering in the apical dendrite and initiated all-or-none dendritic Ca(2+) transients associated with dendritic spikes in layer 5 pyramidal neurons of the prefrontal cortex. The block of… CONTINUE READING
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