Alpha2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity

  title={Alpha2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity},
  author={J. Cai and Jie Li and W. Liu and Y C Han and H. Wang},
Brimonidine, an alpha2-adrenergic receptor (α(2)-AR) agonist, is thought to be neuroprotective in some types of neurons via the activation of α(2)-AR. However, it is still unknown whether the α(2)-ARs exist in cochlear spiral ganglion neurons (SGNs). The authors aimed to demonstrate the presence and localization of α(2)-ARs in rat-cultured SGNs and to investigate the effect of brimonidine on glutamate- and hydrogen peroxide (H(2)O(2))-induced damage in the primary-cultured rat SGNs. The… Expand
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