Alpha2 adrenergic receptor-mediated modulation of cytosolic Ca++ signals at the inner plexiform layer of the rat retina.

@article{Dong2007Alpha2AR,
  title={Alpha2 adrenergic receptor-mediated modulation of cytosolic Ca++ signals at the inner plexiform layer of the rat retina.},
  author={C J Dong and Yuanxing Guo and Larry A. Wheeler and William A. Hare},
  journal={Investigative ophthalmology \& visual science},
  year={2007},
  volume={48 3},
  pages={
          1410-5
        }
}
PURPOSE Compelling evidence suggests that alpha2 agonists, such as brimonidine, protect retinal ganglion cells (RGCs) from injury in a wide range of animal models. However, the mechanism of action for this protection and the physiological role of the alpha2 adrenergic system in the retina is not well understood. A major goal of this work was to explore the role of the alpha2 adrenergic system in the modulation of cytosolic Ca(2+) signaling at retinal synaptic layers, particularly the inner… Expand
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