Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans.

@article{Stefan2006Alpha2HeremansSchmidGI,
  title={Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans.},
  author={Norbert Stefan and Anita M. Hennige and Harald Staiger and J{\"u}rgen Machann and Fritz Schick and Stefan Martin Kr{\"o}ber and Fausto Machicao and Andreas Fritsche and Hans-Ulrich H{\"a}ring},
  journal={Diabetes care},
  year={2006},
  volume={29 4},
  pages={
          853-7
        }
}
  • Norbert Stefan, Anita M. Hennige, +6 authors Hans-Ulrich Häring
  • Published in Diabetes care 2006
  • Medicine
  • OBJECTIVE The alpha(2)-Heremans-Schmid glycoprotein (AHSG; fetuin-A in animals) impairs insulin signaling in vitro and in rodents. Whether AHSG is associated with insulin resistance in humans is under investigation. In an animal model of diet-induced obesity that is commonly associated with hepatic steatosis, an increase in Ahsg mRNA expression was observed in the liver. Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only… CONTINUE READING

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