Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients

@inproceedings{Kato2015Alpha1chimaerinAR,
  title={Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients},
  author={Tomoko Sugiyama Kato and Yoshihiro Konishi and Shun Shimohama and Thomas Gerald Beach and Hiroyasu Akatsu and Ikuo Tooyama},
  booktitle={Neuroscience letters},
  year={2015}
}
Alpha1-chimaerin is a GTPase-activating protein (GAP) for Rac1, a member of the Rho small GTPase family, whose action leads to the inactivation of Rac1. Rac1 activity is upregulated in Alzheimer's disease, but little is known about the role of α1-chimaerin. In this study, we investigated the expression and localization of α1-chimaerin mRNA in postmortem… CONTINUE READING