Alpha1-adrenergic signaling mechanisms in contraction of resistance arteries.

  title={Alpha1-adrenergic signaling mechanisms in contraction of resistance arteries.},
  author={Withrow Gil Wier and Kathleen G Morgan},
  journal={Reviews of physiology, biochemistry and pharmacology},
Our goal in this review is to provide a comprehensive, integrated view of the numerous signaling pathways that are activated by alpha(1)-adrenoceptors and control actin-myosin interactions (i.e., crossbridge cycling and force generation) in mammalian arterial smooth muscle. These signaling pathways may be categorized broadly as leading either to thick (myosin) filament regulation or to thin (actin) filament regulation. Thick filament regulation encompasses both "Ca(2+) activation" and "Ca(2… CONTINUE READING
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