Alpha-tocopherol transfer protein deficiency in mice causes multi-organ deregulation of gene networks and behavioral deficits with age.

@article{Gohil2004AlphatocopherolTP,
  title={Alpha-tocopherol transfer protein deficiency in mice causes multi-organ deregulation of gene networks and behavioral deficits with age.},
  author={Kishorchandra Gohil and Roy Godzdanker and Erin M O'Roark and Bettina C. Schock and Ramesh R Kaini and Lester Packer and Carroll E. Cross and Maret G Traber},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1031},
  pages={109-26}
}
Functions of alpha-tocopherol (alpha-T) in vivo, other than those for fertility in females, are intensely debated. The discovery of alpha-T deficiency in patients with ataxia (AVED) followed by the identification of mutations in the gene encoding alpha-tocopherol transfer protein (TTP) in AVED patients demonstrates an essential role of alpha-T and TTP for normal neurological function. alpha-T molecular targets that account for alpha-T-sensitive neurological dysfunction remain to be discovered… CONTINUE READING
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