Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats

  title={Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats},
  author={Leucio Duarte Vieira-Filho and Edjair Vicente Cabral and Felipe T. J. Santos and Terezila Machado Coimbra and Ana Durce O Paix{\~a}o},
  journal={Pediatric Nephrology},
The role of α-tocopherol during nephrogenesis was investigated in rats subjected to maternal undernutrition, which reduces the number of nephrons. α-tocopherol (350 mg/kg, p.o.) was administered daily to well-nourished or malnourished Wistar dams during pregnancy, or to prenatal undernourished rats during lactation. The kidneys of 1- and 25-day-old offspring were removed to evaluate expression of angiotensin II (Ang II) and to correlate this with expression of proliferating cell nuclear antigen… CONTINUE READING