Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.

  title={Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.},
  author={Debbie J. Mustacich and Scott W. Leonard and Neha K Patel and Maret G Traber},
  journal={Free radical biology & medicine},
  volume={48 1},
Approximately 40% of Americans take dietary supplements, including vitamin E (alpha-tocopherol). Unlike other fat-soluble vitamins, alpha-tocopherol is not accumulated to toxic levels. Rather tissue levels are tightly regulated, in part via increased hepatic metabolism and excretion that could, theoretically, alter metabolism of drugs, environmental toxins, and other nutrients. To date, in vivo subcellular location(s) of alpha-tocopherol metabolism have not been identified. The proposed pathway… CONTINUE READING


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