Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels.

@article{Adamczyk2006AlphasynucleinPC,
  title={Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels.},
  author={Agata Adamczyk and Joanna Benigna Strosznajder},
  journal={Neuroreport},
  year={2006},
  volume={17 18},
  pages={
          1883-6
        }
}
Alpha-synuclein localized in synaptic terminals plays an important role in the pathogenesis of neurodegenerative diseases. The central domain of the protein, the nonamyloid component, is probably responsible for alpha-synuclein toxicity. Here, we report that alpha-synuclein and its nonamyloid component induced Ca2+ influx in rat synaptoneurosomes. The effect of alpha-synuclein was eliminated by the N-type specific Ca2+ channel blocker, omega-conotoxin GVIA. The antioxidant, resveratrol, and the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Similar Papers

Loading similar papers…