Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.

@article{Piao2003AlphasynucleinPA,
  title={Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.},
  author={Y S Piao and Fumiaki Mori and Shintaro Hayashi and Kunikazu Tanji and Makoto Yoshimoto and Akiyoshi Kakita and Koichi Wakabayashi and Hitoshi Takahashi},
  journal={Acta neuropathologica},
  year={2003},
  volume={105 4},
  pages={403-9}
}
We carried out immunohistochemical examinations of the brains (cerebella) of patients who had suffered from Parkinson's disease (PD), diffuse Lewy body disease (DLBD) or multiple system atrophy (MSA), using antibodies specific for alpha-synuclein. Alpha-synuclein-positive doughnut-shaped structures were found occasionally in the cerebellar molecular layer in some of these patients. Double-labeling immunofluorescence and immunoelectron microscopy studies revealed that these alpha-synuclein… CONTINUE READING
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