Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway.

@article{Wu2010AlphasynucleinOI,
  title={Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway.},
  author={Nanping Wu and Prasad R. Joshi and Carlos Cepeda and Eliezer Masliah and Michael S Levine},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 8},
  pages={1764-76}
}
alpha-Synuclein (alpha-Syn) is a presynaptic protein implicated in Parkinson's disease (PD). Mice overexpressing human wildtype (WT) alpha-Syn under the Thy1 promoter show high levels of alpha-Syn in cortical and subcortical regions, exhibit progressive sensorimotor anomalies, as well as non-motor abnormalities and are considered models of pre-manifest PD as there is little evidence of early loss of dopaminergic (DA) neurons. We used whole-cell patch clamp recordings from visually identified… CONTINUE READING