Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.

  title={Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.},
  author={Marusela Oliveras-Salv{\'a} and Francesca Macchi and Val{\'e}rie Coessens and Ang{\'e}lique Deleersnijder and Melanie G{\'e}rard and Anke Van der Perren and Chris Van den Haute and Veerle Baekelandt},
  journal={Neurobiology of aging},
  volume={35 11},
Loss-of-function mutations in the PINK1 gene lead to recessive forms of Parkinson's disease. Animal models with depleted PINK1 expression have failed to reproduce significant nigral dopaminergic neurodegeneration and clear alpha-synuclein pathology, main characteristics of the disease. In this study, we investigated whether alpha-synuclein pathology is altered in the absence of PINK1 in cell culture and in vivo. We observed that downregulation of PINK1 enhanced alpha-synuclein aggregation and… CONTINUE READING
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