Alpha-synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide.

Abstract

Alpha-synuclein (ASN), a 140-amino acid protein, is richly expressed in presynaptic terminals in the central nervous system, where it plays a role in synaptic vesicle function. However, if it is altered and accumulated it is involved in neurodegeneration as Parkinson's disease (PD). ASN contained 35-amino acid domain known as non-amyloid beta component of… (More)

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@article{Adamczyk2006AlphasynucleinAI, title={Alpha-synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide.}, author={Agata Adamczyk and Anna K Kaźmierczak and Joanna Benigna Strosznajder}, journal={Neurochemistry international}, year={2006}, volume={49 4}, pages={407-12} }