Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

Abstract

Multiple system atrophy is a neurodegenerative disorder characterized by accumulation of aggregated Ser-129-phosphorylated alpha-synuclein in oligodendrocytes. p25alpha is an oligodendroglial protein that potently stimulates alpha-synuclein aggregation in vitro. To model multiple system atrophy, we coexpressed human p25alpha and alpha-synuclein in the rat… (More)
DOI: 10.1074/jbc.M809671200

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@article{Kragh2009AlphasynucleinAA, title={Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.}, author={Christine Lund Kragh and Louise B Lund and Fabia Febbraro and Hanne D. Hansen and W Z Gai and Omar M. A. El-Agnaf and Christiane Richter-Landsberg and Poul Henning Jensen}, journal={The Journal of biological chemistry}, year={2009}, volume={284 15}, pages={10211-22} }