Alpha-synuclein: normal function and role in neurodegenerative diseases.

  title={Alpha-synuclein: normal function and role in neurodegenerative diseases.},
  author={Erin H. Norris and Benoit I Giasson and Virginia M-Y Lee},
  journal={Current topics in developmental biology},
Synucleins are a family of small, highly charged proteins expressed predominantly in neurons. Since their discovery and characterization during the last decade, much has been learned about their structure, potential functions, interactions with other proteins, and roles in disease. One of these proteins, alpha-synuclein (alpha-syn), is the major building block of pathological inclusions that characterize many neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 76 extracted citations

Similar Papers

Loading similar papers…