Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.

@article{AmiryMoghaddam2004AlphasyntrophinDR,
  title={Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.},
  author={Mahmood Amiry-Moghaddam and Rong Xue and Finn-Mogens S Haug and John D. Neely and A. Prasad Bhardwaj and Peter Agre and Marvin E. Adams and Stanley C. Froehner and Susumu Mori and Ole Petter Ottersen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 3},
  pages={542-4}
}
The formation of brain edema, commonly occurring as a potentially lethal complication of acute hyponatremia, is delayed following knockout of the water channel aquaporin-4 (AQP4). Here we show by high-resolution immunogold analysis of the blood-brain-barrier that AQP4 is expressed in brain endothelial cells as well as in the perivascular membranes of astrocyte endfeet. A selective removal of perivascular AQP4 by alpha-syntrophin deletion delays the buildup of brain edema (assessed by Diffusion… CONTINUE READING

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