Alpha-smooth muscle actin (alpha-SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor-beta 1 (TGF-beta1).

@article{Moreels2008AlphasmoothMA,
  title={Alpha-smooth muscle actin (alpha-SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor-beta 1 (TGF-beta1).},
  author={Marjan Moreels and Frank Vandenabeele and Dan Dumont and Johan Robben and Ivo Lambrichts},
  journal={Neuropathology and applied neurobiology},
  year={2008},
  volume={34 5},
  pages={532-46}
}
AIMS Rapid and extensive activation of astrocytes occurs subsequent to many forms of central nervous system (CNS) injury. Recent studies have revealed that the expression profile of reactive astrocytes comprises antigens present during astrocyte development. Elevated levels of the injury-related cytokine transforming growth factor-beta 1 (TGF-beta1) secreted by microglial cells and invading macrophages have been correlated with the reactive astrocyte phenotype and glial scar formation… CONTINUE READING
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