Alpha-sheet: The toxic conformer in amyloid diseases?

  title={Alpha-sheet: The toxic conformer in amyloid diseases?},
  author={Valerie Daggett},
  journal={Accounts of chemical research},
  volume={39 9},
A novel secondary structure, the alpha-sheet, was identified through molecular dynamics (MD) simulations of various proteins associated with amyloid diseases under amyloidogenic conditions. The structure was first predicted by Pauling and Corey, and it has been directly observed in crystal structures of "nonnatural peptides". There are occurrences of alpha-strands and alpha-sheets in the Protein Data Bank, but they are rare. We propose that alpha-sheet is formed during the conformational… CONTINUE READING