Alpha sarcoglycan is required for FGF-dependent myogenic progenitor cell proliferation in vitro and in vivo.

@article{Cassano2011AlphaSI,
  title={Alpha sarcoglycan is required for FGF-dependent myogenic progenitor cell proliferation in vitro and in vivo.},
  author={Marco Cassano and Arianna Dellavalle and Francesco Saverio Tedesco and Mattia Quattrocelli and Stefania Crippa and Flavio Ronzoni and Agnese Salvad{\`e} and Emanuele Berardi and Yvan Torrente and Giulio Cossu and Maurilio Sampaolesi},
  journal={Development},
  year={2011},
  volume={138 20},
  pages={4523-33}
}
Mice deficient in α-sarcoglycan (Sgca-null mice) develop progressive muscular dystrophy and serve as a model for human limb girdle muscular dystrophy type 2D. Sgca-null mice suffer a more severe myopathy than that of mdx mice, the model for Duchenne muscular dystrophy. This is the opposite of what is observed in humans and the reason for this is unknown. In an attempt to understand the cellular basis of this severe muscular dystrophy, we isolated clonal populations of myogenic progenitor cells… CONTINUE READING

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