Alpha-naphthylthiourea (ANTU) protects against hyperoxic depression of pulmonary serotonin uptake.

  • Ethan R. Block
  • Published 1982 in The American review of respiratory disease


To evaluate whether alpha-naphthylthioura (ANTU) protects against hyperoxic injury to the pulmonary endothelium, we monitored survival and serotonin uptake by the lungs of ANTU-treated rats (5 mg/kg) and Tween 80-treated control rats exposed to 100% O2 or air at 1 atmosphere absolute. Exposure to 100% O2 for 24 h or 48 h significantly depressed serotonin… (More)


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