Alpha-methyltryptophan as a therapeutic agent

@article{Sourkes1991AlphamethyltryptophanAA,
  title={Alpha-methyltryptophan as a therapeutic agent},
  author={Theodore L. Sourkes},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1991},
  volume={15},
  pages={935-938}
}
  • T. Sourkes
  • Published 31 December 1991
  • Biology, Psychology, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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References

SHOWING 1-10 OF 27 REFERENCES
Alpha-methylserotonin, a substitute transmitter for serotonergic neurons
Metabolism of a-methyltryptophan?
Alpha-methyltryptophan: effects on synthesis and degradation of serotonin in the brain.
Stimulation of tyrosine aminotransferase activity by dl-alpha-methyltryptophan.
  • M. Oravec
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1975
The effect of three tryptamine derivatives on serotonin metabolism in vitro and in vivo.
TLDR
Although it is possible for α-methyltryptamine to inhibit both MAO and 5-hydroxytryptophan decarboxylase in vivo the observed effects would indicate that MAO is predominantly affected.
Decrease of cerebral serotonin and 5‐hydroxyindolylacetic acid caused by (—)‐α‐methyltryptophan 1
TLDR
The effect of AMTP on the concentration of serotonin and its acid metabolite 5H I M (5-hydroxyindolylacetic acid) in the brain is assessed and the availability of the separate isomers of AM TP enabled us to determine the contribution of each to this effect, as well as to other actions of the compound.
THE WEIGHT-DEPRESSING ACTION OF α-METHYL-DL-TRYPTOPHAN IN THE RAT
TLDR
Ina search for an explanation for the weight-depressing action of α-methyltryptophan, tryptophan pyrrolase activity in the liver was estimated and enzymic activity increases for 8 hours after the injection, and thereafter remains high for 72 hours.
Effect of α-methylserotonin on serotonin receptor-coupled phosphoinositide breakdown in rat cerebral cortex
Behaviour of α-methylserotonin in rat brain synaptosomes
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